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Saturday, August 1, 2020 | History

3 edition of HDL deficiency and atherosclerosis found in the catalog.

HDL deficiency and atherosclerosis

HDL deficiency and atherosclerosis

  • 280 Want to read
  • 12 Currently reading

Published by Kluwer Academic Publishers in Dordrecht, Boston .
Written in English

    Subjects:
  • Atherosclerosis -- Molecular aspects.,
  • High density lipoproteins -- Metabolism -- Disorders.,
  • Hypolipoproteinemia.,
  • Lipoproteins, HDL Cholesterol -- deficiency.,
  • Lipoproteins, HDL Cholesterol -- metabolism.,
  • Atherosclerosis -- metabolism.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by G. Assmann.
    SeriesDevelopments in cardiovascular medicine ;, v. 174
    ContributionsAssmann, G.
    Classifications
    LC ClassificationsRC692 .H38 1995
    The Physical Object
    Paginationx, 84 p. :
    Number of Pages84
    ID Numbers
    Open LibraryOL795947M
    ISBN 100792388887
    LC Control Number95031820

      Patients with extremely low high-density lipoprotein-cholesterol (HDL-C) pose distinct challenges to clinical diagnosis and management. Confirmation of HDL-C levels below 20 mg/dl in the absence of severe hypertriglyceridemia should be followed by evaluation for secondary causes, such as androgen use, malignancy, and primary monogenic disorders Cited by: The C57BL/6 strain differs from most inbred strains by having lower HDL concentrations and a high risk of developing early atherosclerotic lesions when fed an atherogenic diet. The relative HDL deficiency and atherosclerosis susceptibility of the C57BL/6 strain are corrected with the expression Cited by:

    Certain hypotheses, like increasing pre-B-HDL (the major ligand of the ABCA1 transporter that drives CEC) have already been tested with mixed results. 17 Two trials, the Effect of rHDL on Atherosclerosis-Safety and Efficacy (ERASE) Trial and Selective Delipidation Trial demonstrated that increased pre-B-HDL (by infusion and delipidation. Introduction. Arteriosclerosis is the missing link between strokes and heart y, the Framingham Heart Study and many other newer prospective studies have shown that the degree of hardening of the arteries throughout the body, called “arteriosclerosis” or “atherosclerosis”, determines the risk of whether or not we are developing strokes and heart attacks (Ref. 1, 5 and 6).

      HDL is known as “good cholesterol” because it transports cholesterol to your liver to be expelled from your body. HDL helps rid your body of excess cholesterol so it’s less likely to end up Author: Annette Mcdermott. The strong inverse association between HDL cholesterol concentration and atherosclerosis risk (Gordon et al., ) has fuelled the study of CETP as a modulator of cardiovascular disease. The expression of CETP in wild type, LDL receptor knockout and apolipoprotein E knockout.


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HDL deficiency and atherosclerosis Download PDF EPUB FB2

The tandem pace of medical knowledge and prevention of ischaemic heart disease over the past 50 years is testimony to the effectiveness of a combination of massive scientific research, continuous transfer of the results to medical practice, community actions and population aware­ ness. The deathBrand: Springer Netherlands.

For twenty years the HDL have been considered a defence against the caprices of the LDL, now believed to be particularly villainous after oxidation. Keywords Lipoprotein atherosclerosis cardiovascular coronary heart disease gene therapy genetics heart heart disease high-density lipoprotein (HDL).

This volume deals with many of the contemporary puzzles. One theme revolves about the high density lipoproteins. For twenty years the HDL have been considered a defence against the caprices of the LDL, now believed to be particularly villainous after : Springer Netherlands.

Compre HDL Deficiency and Atherosclerosis: Proceedings of a Symposium on "HDL Deficiency and Atherosclerosis" Held in Munster, Germany, September 7, (Developments Medicine Book ) (English Edition) de Assmann, G.

na Confira também os eBooks mais vendidos, lançamentos e livros digitais : Kindle. Pages Abstract High-density lipoprotein (HDL) is an antiatherogenic lipoprotein involved in the reverse cholesterol transport (RCT), which involves cholesterol efflux and its transport back to the liver. HDL has a variety of antiatherogenic functions; however, it can sometimes become dysfunctional.

LCAT deficiency and atherosclerosis. HDL cholesterol level is a strong inverse predictor of cardiovascular events. HDL is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction.9, LCAT deficiency HDL deficiency and atherosclerosis book a metabolic disorder characterized by very low HDL by: Lee "HDL Deficiency and Atherosclerosis" por disponible en Rakuten Kobo.

The tandem pace of medical knowledge and prevention of ischaemic heart disease over the past 50 years is testimony to th Brand: Springer Netherlands. Furthermore, we describe many beneficial properties of HDL that antagonize atherosclerosis and how HDL dysfunction may promote cardiometabolic disease.

Atherosclerosis is the underlying cause of heart attack and stroke. Figure 4 Native human HDL-cholesterol and apoA-I-containing reconstituted HDL-cholesterol inhibit the increase in E-selectin expression induced by C-reactive cent inhibitions were calculated from mean levels of expression of E-selectin before and after exposure to HDL-cholesterol and/or C-reactive protein (mean expression after stimulation by C-reactive protein=%).Cited by: Therefore, high amount of HDL-C in case of CETP deficiency is not always protective of atherosclerosis.

We have experienced two entirely different types of such diseases and treated with hormone replacement therapy (HRT) for the past ten years and reported the clinical significance of HRT for : Maria de Lourdes Guarnieri Barbosa Bueno.

17 rows    Familial HDL deficiency is a rare genetic condition that causes low levels of. HDL deficiency and atherosclerosis: lessons from Tangier disease Dear Sir, Low high-density lipoprotein cholesterol (HDL-C) is a strong risk factor for coronary artery disease (CAD). It is not clear, however, whether this also applies to individuals with Tangier disease (TD), who due to mutations in the ATP-binding cassette A1Cited by: HDL deficiency and atherosclerosis: lessons from Tangier disease.

Thus, high levels of total cholesterol, LDL and HDL have been noticed in people with iodine deficiency. Once the deficiency was treated, remarkable changes in the lipid profile were also noted.

As you may probably see, iodine interferes in the oxidation phase of atherosclerosis due to its anti-inflammatory, anti-proliferative and anti-microbial. This review aims to provide an overview on the properties of high-density lipoproteins (HDLs) and their cardioprotective effects.

Emergent HDL therapies will be presented in the context of the current understanding of HDL function, metabolism, and protective antiatherosclerotic properties. The epidemiological association between levels of HDL-C or its major apolipoprotein (apoA-I) is strong Cited by: HDL deficiency and atherosclerosis: Lessons from Tangier disease [1] Article in Journal of Internal Medicine (2) March with 64 Reads How we measure 'reads'.

Molecular genetics approach to lipoprotein metabolism disorders --Role of high density lipoprotein subclasses in reverse cholesterol transport --Connection between cholesterol efflux and atherosclerosis --HDLC as a therapeutic target in coronary disease: current concepts and future directions --Intracellular cholesterol transport --Apolipoprotein E and Alzheimer's disease --HDL metabolism and.

High cholesterol levels lead to clogged arteries, which can ultimately lead to heart disease. WebMD explains how cholesterol levels - both good and bad - raise the risk of heart attacks and strokes. In extreme examples of HDL deficiency, such as Tangier disease and fish eye disease, serum PON1 is profoundly diminished, 58 59 but in other HDL deficiencies, this is not always the case.

60 This may be relevant to why some HDL deficiency states are associated with premature coronary heart disease (CHD), but others are not. What is certain Cited by: Lipid Lowering Drugs - Hyperlipidemia and Atherosclerosis Last updated; Save as PDF Page ID ; No headers.

Atherosclerosis: A chronic inflammatory disease characterized by enzymatic destruction of the normal arterial skeleton (largely elastin, collagen and smooth muscle), and replacement by disorganized collagen and elastin, cholesterol, and foam cells. HDL Deficiency and Atherosclerosis.

[G Assmann] -- The discovery that plasma cholesterol and lipoprotein concentrations are major predictors of risk has been one of the most important factors behind the dramatic and steady reduction in deaths due to. Familial HDL deficiency is a condition characterized by low levels of high-density lipoprotein (HDL) in the blood.

HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver.Blood Cholesterol Recommendations.

For healthy total blood cholesterol, the desired range you would want to maintain is under mg/dL. More specifically, when looking at individual lipid profiles, a low amount of LDL and a high amount of HDL prevents excess buildup of cholesterol in the arteries and wards off potential health hazards.